Treatment Strategy Tracker
Mapping every treatment strategy to the Kv7/VGCC neurological model. Green = covered, yellow = partial, red = gap that needs attention.
← Understanding the neurological modelCoverage Summary
22 strategies tracked across 4 categories
13
✅ Active
3
⚠️ Partial
4
❌ Gap
2
❓ Unknown
Strategy Coverage Matrix
Priority Gaps
Inositol (PIP2 precursor)
Support M-Current (Keep Kv7 Open)
⚠️ MAJOR GAP — currently ~100x below therapeutic target (25mg vs 2,000-3,000mg needed)
EMF mitigation
Prevent VGCC Overactivation
Environmental assessment needed
EMF reduction
Prevent Kv7 Suppression
Reduce EMF exposure
Avoid PIP2 Depletion
Verapamil (calcium channel blocker)
Prevent VGCC Overactivation
Discuss with MD — prescription calcium channel blocker
Prevent VGCC Overactivation
Slow down the "gas pedal" — reduce excess calcium entry
Magnesium (Ca channel blocker)
Magnesium naturally blocks calcium channels, reducing excess calcium influx into neurons.
NAC (oxidative stress reducer)
N-Acetyl Cysteine reduces oxidative stress that triggers VGCC overactivation.
Vitamin E (lipid protection)
Protects cell membrane lipids from oxidative damage that opens VGCCs.
CoQ10 (oxidative damage)
Mitochondrial antioxidant — reduces oxidative damage that activates VGCCs.
EMF mitigation
EMF directly activates VGCCs. Reducing exposure lowers calcium channel activation.
Environmental assessment needed
Omega-3 EPA/DHA
Anti-inflammatory, membrane stabilizer — helps calm VGCC overactivation.
SPM is targeted but standard EPA/DHA supplementation may also be needed
Mycotoxin detox protocol
Remove the toxins that are directly activating VGCCs and damaging neurons.
Verapamil (calcium channel blocker)
Prescription VGCC blocker — directly reduces calcium entry. Used off-label.
Discuss with MD — prescription calcium channel blocker
Support M-Current (Keep Kv7 Open)
Strengthen the "brake" — help neurons calm down
Inositol (PIP2 precursor)
PIP2 is the "key" that keeps Kv7 channels open. Inositol is the building block for PIP2. Need 2-3g/day.
⚠️ MAJOR GAP — currently ~100x below therapeutic target (25mg vs 2,000-3,000mg needed)
Phosphatidylcholine (500-1000mg/day)
Membrane lipid that supports PIP2 synthesis and Kv7 channel function.
Zinc (Kv7 stability)
Zinc stabilizes Kv7 channel structure and function.
CoQ10 (ATP for channels)
Ion channels need ATP to function. CoQ10 supports mitochondrial ATP production.
Magnesium
Supports Kv7 channel function and reduces opposing calcium channel activity.
Prevent Kv7 Suppression
Protect the brake from further damage
Antioxidants (NAC, Vit E, polyphenols)
Oxidative stress directly damages Kv7 channels. Antioxidants protect them.
NAC added 3/31/2026 — targeted antioxidant coverage now strong
Reduce intracellular calcium
Excess intracellular calcium suppresses Kv7. Magnesium helps block calcium entry.
EMF reduction
EMF activates VGCCs → excess calcium → Kv7 suppression. A double hit.
Anti-inflammatory protocol
Inflammation depletes PIP2 and damages channels. Binders + omega-3 reduce inflammation.
Support lipid metabolism
Kv7 channels sit in lipid membranes. Healthy lipids = healthy channels.
Avoid PIP2 Depletion
Protect the "key" that keeps Kv7 channels open
Reduce oxidative stress
Oxidative stress depletes PIP2 from cell membranes.
Reduce EMF exposure
EMF increases oxidative stress → PIP2 depletion.
Reduce mycotoxin exposure
Mycotoxins directly damage membranes and deplete PIP2.
Detox is happening but source exposure may be ongoing
Support lipid metabolism
PIP2 is a lipid. Supporting lipid metabolism helps replenish it.
Understand the Model
Visual explanation of the Kv7/VGCC mechanism →